Spleen is a ductless organ located in the upper left quadrant of the abdomen just below diaphragm protected under the lower left ribs. It filters the blood and maintains healthy red and white blood cells and platelets. Because this sensitive organ is normally tucked away underneath the ribcage, it is protected from potential dangers that could cause it to tear, which would lead to serious internal hemorrhaging (bleeding). Normally, the spleen is a small organ about the size of a small fist or orange.
Splenomegaly describes the situation where the spleen enlarges in size. Hypersplenism is the name given to the condition where the spleen becomes overactive and destroys more blood cells than it should. Symptoms depend on which blood component is lacking.
For example, if red blood cells are deficient, anaemia will result (with symptoms including fatigue and pallor). Most cases of hypersplenism are caused by disorders somewhere else in the body, such as cirrhosis of the liver. Cause An enlarged spleen can be caused by infections, cirrhosis and other liver diseases, blood diseases characterized by abnormal blood cells, problems with the lymph system, or other conditions.
The causes of splenomegaly vary widely and range from malignancy (cancers), infections, congestion (increased blood flow), infiltration of the spleen from other diseases, inflammatory conditions, and blood cell diseases.
Some of the most common causes of an enlarged spleen include the following: