This is a chronic progressive granulomatous diseases of the vulva, vagina, or cervix. It is commonly found in some tropics and subtropics like South China, South India, Papua New Guinea, and South America.
Causative organism: - The causative organism is a Gram-negative intracellular bacillus—Calymmatobacterium granulomatis
Clinical Features: The disease usually manifests itself 10–80 days after coitus with an infected partner. The lesion starts as pustules, which breakdown and erode the adjacent tissues through continuity and contiguity. The ulcer looks hypertrophic (beefy red) due to indurated granulation tissue. The margins are rolled and elevated. Biopsy may be needed to exclude neoplasia. The lymph nodes do not undergo suppuration and abscess formation (cf. Lymphogranuloma venereum).
Diagnosis is confirmed by demonstrating the Donovan bodies within the mononuclear cells in material (scrapings) from the ulcer when stained by the Giemsa method. Donovan bodies are clusters of dark-staining bacteria with a bipolar (safety pin) appearance found within the mononuclear cells.
The medicines that can be thought of use are:-
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