IDIOPATHIC MYELOFIBROSIS

This rare entity is characterized by marrow fibrosis, myeloid metaplasia with extramedullary hematopoiesis, and splenomegaly. Evaluation of a blood smear reveals teardrop-shaped RBC, nucleated RBC, and some early granulocytic forms, including promyelocytes. However, many entities may lead to marrow fibrosis and extramedullary hematopoiesis, and the diagnosis of primary idiopathic myelofibrosis is made only when the many other potential causes are ruled out.

The following diseases are in the differential diagnosis: CML, polycythemia vera, Hodgkin’s disease, cancer metastatic to the marrow (especially from breast and prostate), infection (particularly granulomatous infections), and hairy cell leukemia. Supportive therapy is generally used; novel inhibitors of JAK2 have shown activity in reducing splenomegaly; however, no study has yet shown a particular drug therapy to improve survival.

HOMEOPATHIC MANAGEMENT: -

The medicines that can be thought of use are: -

• Arsenic iod
• Natrum sulph
• Kali sulph
• Phosphorus
• Thiosinaminum